Related Experiment Video
Updated: May 5, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
Published on: October 17, 2025
A Sequential Design for Extreme Quantile Estimation Under Binary Sampling
Michel Broniatowski1, Emilie Miranda1
1Laboratoire de Probabilités, Statistique et Modélisation (LPSM), CNRS UMR 8001, Sorbonne Universite, 75005 Paris, France.
None:
We propose a sequential design method aiming at the estimation of an extreme quantile based on a sample of binary data corresponding to peaks over a given threshold. This study is motivated by an industrial challenge in material reliability and consists of estimating a failure quantile from trials whose outcomes are reduced to indicators of whether the specimen has failed at the tested stress levels. The proposed approach relies on a splitting strategy that decomposes the target extreme probability into a product of higher-order conditional probabilities, enabling a progressive exploration of the tail of the distribution through sampling under truncated laws. We consider GEV and Weibull models for the underlying distribution, and the sequential estimation of their parameters is carried out using an enhanced maximum likelihood procedure specifically adapted to binary data, addressing the substantial uncertainty inherent to such limited information.
Related Concept Videos
Distributions to Estimate Population Parameter
Detection of Gross Error: The Q Test
Choosing Between z and t Distribution
Censoring Survival Data
Wald-Wolfowitz Runs Test I
The test works...
Random Sampling Method

