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Clinicopathological Features of Extranodal Head and Neck Lymphomas
Füruzan Kacar Döger1, Büşra Ekinci2, Yeşim Başal3
1Department of Pathology, Aydın Atatürk State Hospital, Aydın 09020, Turkey.
Diagnostics (Basel, Switzerland)
|May 4, 2026
Summary
Primary head and neck lymphomas are rare but require careful diagnosis. Diffuse large B-cell lymphoma (DLBCL) is the most common type, often found in the tonsil, with a 12.9% mortality rate.
Area of Science:
- Oncology
- Pathology
- Hematology
Background:
- Primary extranodal lymphomas in the head and neck are uncommon and represent a distinct group.
- Accurate diagnosis and differential diagnosis of these lymphomas are crucial.
Purpose of the Study:
- To retrospectively analyze patients with primary head and neck lymphomas.
- To evaluate histopathological subtypes, locations, frequencies, and survival rates.
Main Methods:
- Retrospective review of 31 head and neck lymphoma cases.
- Histopathological re-evaluation using light microscopy and immunohistochemistry.
- Classification according to the World Health Organization (WHO) guidelines.
Main Results:
- Diffuse large B-cell lymphoma (DLBCL) was the most frequent type (54.8%).
- The tonsil was the most common site (38.7%).
- Overall survival showed a 12.9% mortality rate and a median survival of 28 months.
Conclusions:
- Malignant lymphoma should be considered in head and neck masses.
- Histopathological assessment is essential for diagnosis.
- Understanding subtypes and locations aids in patient management.
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