Related Experiment Video

Updated: May 5, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

825

Feasibility and Policy Implications of a Pragmatically Adapted Pediatric-Inspired Induction Regimen for Adults with

Sadia Qazi1, Hafsa Fayyaz2, Bilal Ahmad3

  • 1Department of Anatomy, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.

Healthcare (Basel, Switzerland)
|May 4, 2026
PubMed

Insights

An adapted pediatric-inspired regimen for adult Acute Lymphoblastic Leukemia (ALL) showed feasibility and favorable outcomes in Pakistan. Challenges in diagnostic capacity and financial protection hinder risk-adapted care.

Area of Science:

  • Hematology
  • Oncology
  • Global Health

Background:

  • Pediatric-inspired regimens for Acute Lymphoblastic Leukemia (ALL) face implementation barriers in low- and middle-income countries.
  • Diagnostic gaps, unstable procurement, and limited supportive care capacity hinder ALL treatment.
  • Adapting regimens is crucial for improving outcomes in resource-restricted settings.

Purpose of the Study:

  • To evaluate the feasibility, safety, and affordability of an adapted pediatric-inspired induction regimen for adults with Philadelphia chromosome-negative (Ph(-)) ALL in Pakistan.
  • To assess complete remission rates and identify toxicities associated with the adapted regimen.
  • To analyze the economic impact and service delivery indicators of the adapted regimen.

Main Methods:

  • Prospective single-center cohort study of 200 adults (18-50 years) with newly diagnosed Ph(-)ALL.
  • Administered an adapted pediatric-inspired induction regimen.
  • Assessed complete remission (CR), early mortality, treatment abandonment, grade 3-4 toxicities, and out-of-pocket diagnostic costs.

Main Results:

  • Complete remission (CR) achieved in 83.0% of patients.
  • Low rates of early mortality (2.0%) and treatment abandonment (1.5%).
  • Significant disparities in diagnostic costs observed, impacting affordability for poorer households.

Conclusions:

  • The adapted pediatric-inspired induction regimen is operationally deliverable and yields favorable outcomes in resource-restricted settings.
  • Limited diagnostic capacity and lack of financial protection for testing are significant barriers.
  • Expanding diagnostic subsidies and stabilizing procurement are key to improving implementation and risk-adapted care.

Keywords:
LMICsPakistanacute lymphoblastic leukemiaaffordabilitydiagnostic accessfeasibilityhealth policypediatric-inspired induction

More Related Videos

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

17.5K
Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

32.2K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
408
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
967
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
3.0K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
554