Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

3.7K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
3.7K
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

3.3K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
3.3K
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

53
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
53
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.2K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.2K
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

6.2K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
6.2K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

6.7K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuromuscular Disorders: Recent Advances and Open Challenges.

Brain sciences·2026
Same author

Deep Phenotyping of F64L Mutation in a Multicentric Cohort of Patisiran-Treated Hereditary Transthyretin Amyloidosis Patients (Patisiranitaly).

European journal of neurology·2026
Same author

Emotional intelligence, perceived stress, and life satisfaction among university students: examining direct and moderating relationships.

Frontiers in psychology·2026
Same author

Efgartigimod in Patients with Generalized Myasthenia Gravis Refractory or Intolerant to IVIg.

Neurology and therapy·2026
Same author

Natural Killer Subset Changes and Vascular Endothelial Growth Factor-A Plasma Profile in Progressive Supranuclear Palsy: The NKscape Study.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Advanced Parkinson's disease treatment patterns in Italy: results from a multicenter observational study.

Annals of medicine·2026
Same journal

Correction: Haddock et al. <i>Imagine the Possibilities Pain Coalition</i> and Opioid Marketing to Veterans: Lessons for Military and Veterans Healthcare. <i>Healthcare</i> 2025, <i>13</i>, 434.

Healthcare (Basel, Switzerland)·2026
Same journal

Macro Responsibility in the Microvascular World: Nurse Experiences in Flap Care, a Phenomenological Study.

Healthcare (Basel, Switzerland)·2026
Same journal

Agreement Between Standing Eight-Point Multifrequency Bioelectrical Impedance Analysis and Dual-Energy X-Ray Absorptiometry for Body Composition Assessment in Apparently Healthy Greek Adults.

Healthcare (Basel, Switzerland)·2026
Same journal

'It's Not About the Food'-Understanding the Lived Experience of Patients Who Developed Hospital-Acquired Malnutrition (HAM) and That of Their Carers.

Healthcare (Basel, Switzerland)·2026
Same journal

Unveiling the Humanizing and Therapeutic Values of Live Music in Healthcare Settings: A Scoping Review.

Healthcare (Basel, Switzerland)·2026
Same journal

Respiratory Rehabilitation and Decannulation in Adults with Prolonged Mechanical Ventilation After Tracheostomy: A Narrative Review.

Healthcare (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
07:10

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

9.4K

Physical Exercise in Myasthenia Gravis: A Systematic Review.

Claudia Vinciguerra1, Ignazio Leale2, Nicasio Rini3

  • 1Neurology Unit, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University Hospital San Giovanni di Dio e Ruggi d'Aragona, 84131 Salerno, Italy.

Healthcare (Basel, Switzerland)
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

Structured exercise programs show promise for individuals with myasthenia gravis (MG), improving function and quality of life without worsening symptoms. Further research is needed to confirm long-term benefits.

Keywords:
aerobic trainingexercisemyasthenia gravisquality of liferesistance training

More Related Videos

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

13.8K
Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

16.2K

Related Experiment Videos

Last Updated: May 5, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
07:10

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

9.4K
Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

13.8K
Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

16.2K

Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Autoimmune Diseases

Background:

  • Myasthenia gravis (MG) is a chronic autoimmune condition causing progressive muscle weakness and fatigue.
  • Historically, exercise was contraindicated in MG due to fears of symptom exacerbation.
  • Emerging evidence suggests structured exercise may be safe and beneficial for stable MG patients.

Purpose of the Study:

  • To systematically review the evidence on exercise and physical activity interventions in MG.
  • To evaluate the effectiveness, safety, and impact on functional outcomes, fatigue, and quality of life (QoL).

Main Methods:

  • Systematic review following PRISMA guidelines.
  • Searched databases (PubMed, Web of Science, etc.) for studies from 2015-2025.
  • Assessed methodological quality using the Downs and Black checklist.

Main Results:

  • Eight controlled studies included aerobic, resistance, and respiratory muscle training.
  • Exercise interventions were generally well-tolerated with no sustained symptom exacerbation.
  • Aerobic and combined programs improved functional capacity and strength; respiratory training improved pulmonary function.

Conclusions:

  • Individualized, symptom-guided exercise is likely safe and effective for stable MG.
  • Regular physical activity can reduce deconditioning and enhance QoL.
  • High-quality RCTs with longer follow-up are needed to solidify recommendations.