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Related Experiment Video

Updated: May 5, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Children's Behavioral Development in Correlation with Postpartum Mental Health During Pandemic Period.

Arianna Capocasale1,2, Luca Liberati3, Danilo Buonsenso4

  • 1Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

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Summary

Children born to mothers with postpartum depressive symptoms showed fewer internalizing behaviors after the COVID-19 pandemic. However, age differences between study groups require cautious interpretation of these findings on child behavior outcomes.

Keywords:
behavioral outcomeschild behavior checklistmaternal moodpandemicpediatric awarenesspostpartum depressionpreschool childrensocioemotional development

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Area of Science:

  • Child Psychology
  • Public Health
  • Epidemiology

Background:

  • Maternal postpartum depressive symptoms and the COVID-19 pandemic are risk factors for child socioemotional difficulties.
  • Previous research highlights the impact of maternal mental health and global events on child development.

Purpose of the Study:

  • To assess behavioral outcomes in young children using the Child Behavior Checklist (CBCL 1½-5).
  • To compare children born to mothers screened for postpartum depressive symptoms, evaluated during and after the COVID-19 pandemic.

Main Methods:

  • An observational follow-up cohort study of 52 mother-child dyads.
  • Two cohorts: during-pandemic (Jan-Apr 2022) and post-pandemic (Oct-Nov 2023).
  • Screening with Edinburgh Postnatal Depression Scale (EPDS) and behavioral assessment with CBCL 1½-5.

Main Results:

  • Children in the post-pandemic cohort had fewer internalizing scores compared to the during-pandemic cohort.
  • No significant differences in externalizing outcomes or Total Problems between cohorts.
  • Maternal SARS-CoV-2 infection at delivery was not linked to child behavioral outcomes.

Conclusions:

  • A potential difference in internalizing behaviors exists between children assessed during and after the pandemic.
  • Age differences at follow-up may influence observed behavioral patterns.
  • Longitudinal studies are needed to confirm if these differences persist over time.