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ACE-Inhibitory Peptides from Yanbian Cattle Hemoglobin: Screening, Kinetics, and Molecular Dynamics Simulation.

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Yanbian cattle hemoglobin yields potent ACE-inhibitory peptides. These natural compounds show promise for managing hypertension and could be used in functional foods.

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Area of Science:

  • Biochemistry
  • Food Science
  • Pharmacology

Background:

  • Hypertension is a growing global health concern requiring novel treatments.
  • Synthetic Angiotensin-Converting Enzyme (ACE) inhibitors have side effects, driving research into natural alternatives.
  • Bovine hemoglobin is explored as a source for ACE inhibitory peptides.

Purpose of the Study:

  • To identify and characterize ACE inhibitory peptides from Yanbian cattle hemoglobin.
  • To evaluate the antihypertensive potential of these peptides.

Main Methods:

  • Hemoglobin hydrolysis and peptide fractionation by molecular weight.
  • Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS) for peptide identification.
  • Solid-phase synthesis, enzyme kinetics, molecular dynamics simulations, and HUVEC functional assays.

Main Results:

  • The <1 kDa fraction showed the highest ACE inhibitory activity.
  • NFGYDL peptide exhibited the strongest inhibition (IC50 = 54.95 μM).
  • Four peptides demonstrated stable binding to ACE and enhanced nitric oxide production in HUVEC assays.

Conclusions:

  • Bovine blood is a viable source of natural ACE-inhibitory peptides.
  • Identified peptides possess potential antihypertensive properties.
  • These peptides may be applicable in functional foods for hypertension management.