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Updated: May 5, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Anti-Tumor Immunity in Solid-Organ Transplant Recipients.

Jeffrey Sum Lung Wong¹, Karen Hoi Lam Li¹, Bryan Li^1,2

¹Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.

|May 4, 2026

Summary

Solid-organ transplant recipients face higher cancer risks due to dampened anti-tumor immunity. Further research is vital to enhance cancer immunity while preserving transplanted organs.

Keywords:

anti-tumor immunity immune checkpoint inhibitors solid-organ tumors transplant oncology

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Area of Science:

Oncology
Immunology
Transplantation Science

Background:

Solid-organ transplant (SOT) recipients exhibit elevated malignancy risks and poorer oncological outcomes.
Factors unique to transplantation, including immunosuppression and comorbidities, impair anti-tumor immunity.

Purpose of the Study:

To review the impact of impaired anti-tumor immunity on cancer treatment efficacy in SOT recipients.
To assess the efficacy of systemic therapies, including immune checkpoint inhibitors (ICIs), in SOT patients.

Main Methods:

Review of retrospective clinical data and case reports on systemic therapies in SOT recipients.
Analysis of treatment efficacy for ICIs, chemotherapy, and targeted therapies in various cancers post-transplant.

Main Results:

ICI efficacy is preserved for cutaneous squamous cell carcinomas but diminished for other tumors in SOT recipients.
Chemotherapy for colorectal cancer and sorafenib/lenvatinib for hepatocellular carcinoma appear effective in SOT recipients.
Limited evidence exists for other systemic agents, often from low-quality studies.

Conclusions:

Impaired anti-tumor immunity in SOT recipients affects cancer treatment outcomes.
Strategies to boost anti-tumor immunity while ensuring graft survival are critically needed.
Further clinical and translational studies are essential given the increasing number of cancer patients undergoing transplantation.