Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Extrinsic and Intrinsic Pathways of Hemostasis

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...

Coagulation

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...

Coagulation

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...

Introduction to Hemostasis

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Compatibility of Trapped Ions and Dielectrics at Cryogenic Temperatures.

Physical review letters·2026

Same author

First-trimester occupational exposures and hypertensive disorders of pregnancy among US nurses.

Occupational medicine (Oxford, England)·2023

Same author

Pediatric emergency department physicians' perceptions of virtual mental health assessments for urgent needs.

CJEM·2023

Same author

Implementing post-normal science with or for EU policy actors: using quantitative story-telling.

Sustainability science·2023

Same author

Design and function of targeted endocannabinoid nanoparticles.

Scientific reports·2022

Same author

Publisher Correction: Integrated multi-wavelength control of an ion qubit.

Nature·2021

Search research articles

Related Experiment Video

Updated: Jun 15, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Serial changes in coagulation and viscosity during sickle-cell crisis.

S G Richardson, K B Matthews, J Stuart

British Journal of Haematology

|January 1, 1979

Summary

Painful crisis in sickle-cell anaemia involves increased coagulation and blood viscosity. These changes, similar to infection responses, may worsen vascular occlusion alongside sickled cells.

More Related Videos

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

Related Experiment Videos

Last Updated: Jun 15, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

Area of Science:

Hematology
Vascular Biology
Sickle Cell Disease Pathophysiology

Background:

Sickle-cell anaemia is characterized by vaso-occlusive events.
The role of coagulation and blood viscosity during sickle-cell crisis requires further elucidation.

Purpose of the Study:

To investigate coagulation activity and whole-blood viscosity in sickle-cell anaemia patients during steady state and painful crisis.
To compare these changes with those observed in patients with infection but without sickle-cell anaemia.

Main Methods:

Measured coagulation activity and whole-blood viscosity in 8 sickle-cell anaemia patients.
Assessed these parameters serially during painful crisis.
Conducted a parallel study on 20 patients with localized bacterial or viral infection.

Main Results:

Platelet and coagulation activation were observed in the steady state and intensified during crisis in sickle-cell anaemia patients.
Whole-blood viscosity increased during crisis, correlating with plasma fibrinogen levels.
Similar changes in viscosity and coagulation were noted in patients with infection, suggesting a shared acute-phase response.

Conclusions:

Increased coagulation and blood viscosity during sickle-cell crisis are secondary to vascular stasis, infection, and acute-phase protein reactions.
These secondary changes may exacerbate vascular occlusion in sickle-cell disease by additive effects on already compromised vessels.