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Related Concept Videos

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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PRDM Proteins Orchestrate Colorectal Cancer Tumorigenesis.

Erika Di Zazzo1, Carmela Sorrentino2, Monica Rienzo3

  • 1Department of Medicine and Health Sciences "V. Tiberio", University of Molise, 86100 Campobasso, Italy.

International Journal of Molecular Sciences
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

PRDM proteins are key regulators in colorectal cancer (CRC) development, acting as tumor suppressors or oncogenes. They offer potential as biomarkers and therapeutic targets for CRC.

Keywords:
PRDMcancer biomarkerscolorectal cancerconsensus molecular subtypes (CMS)oncogenetumor suppressor

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Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Colorectal cancer (CRC) is a complex disease influenced by genetic, epigenetic, and microenvironmental factors.
  • The PR domain-containing (PRDM) protein family plays a significant role in CRC.
  • PRDM proteins exhibit context-dependent functions in CRC initiation, progression, and treatment response.

Purpose of the Study:

  • To explore the multifaceted roles of PRDM proteins in colorectal cancer.
  • To highlight the potential of PRDM family members as biomarkers and therapeutic targets in CRC.

Main Methods:

  • Review of accumulating evidence on PRDM protein family in CRC.
  • Analysis of PRDM protein functions including tumor suppression, oncogenesis, and isoform-dependent regulation.

Main Results:

  • PRDM proteins act as context-dependent regulators in CRC.
  • Divergent roles observed: tumor suppressors, oncogenes, or dual-function regulators.
  • PRDM family represents a central control node for transcriptional and epigenetic regulation in CRC.

Conclusions:

  • PRDM proteins are crucial in CRC biology.
  • Significant potential for PRDM family members as biomarkers for early detection, prognosis, and treatment stratification.
  • PRDM proteins are promising candidates for epigenetic and pathway-directed therapeutic strategies in CRC.