Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Self-Assembled Nanoparticles from Cationic Dipeptides and D-π-A Chromophores for Near-Infrared Photothermal Therapy.

International journal of molecular sciences·2025

Same author

Inorganic and organic hybrid nanoarchitectonics for biomedical application.

Advances in colloid and interface science·2025

Same author

One-pot assembling pyrroloquinoline quinone glucose dehydrogenase with polydopamine to overcome the reproducibility issues of layer-by-layer electrode development.

Sensors & diagnostics·2025

Same author

Self-powered, ultrabroad band photodetectors with large open circuit voltage using colloidal PbSe QDs.

Nanoscale advances·2025

Same author

Probing Peptide Assembly and Interaction via High-Resolution Imaging Techniques: A Mini Review.

International journal of molecular sciences·2025

Same author

Superior performance lithium-ion battery anode based on Co<sub>9</sub>S<sub>8</sub> nanoparticles layered in-situ growth with capacitive synergy.

Journal of colloid and interface science·2025

Search research articles

Related Experiment Video

Updated: May 5, 2026

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Published on: December 16, 2016

Self-Assembling Short Peptide Carriers for Gene Delivery.

Longyu An^1,2, Zhanyao Xu^1,2, Xiaoming Zhang^1,2

¹School of Science, Minzu University of China, Beijing 100081, China.

International Journal of Molecular Sciences

|May 4, 2026

Summary

Self-assembling peptides offer a programmable, biocompatible alternative for gene therapy delivery, overcoming limitations of viral vectors. This review explores their design, function, and potential in mRNA vaccines and gene editing applications.

Keywords:

biocompatibility gene delivery nanomedicine non-viral vectors self-assembly short peptides supramolecular chemistry

More Related Videos

Direct Protein Delivery to Mammalian Cells Using Cell-permeable Cys2-His2 Zinc-finger Domains

Direct Protein Delivery to Mammalian Cells Using Cell-permeable Cys2-His2 Zinc-finger Domains

Published on: March 25, 2015

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Related Experiment Videos

Last Updated: May 5, 2026

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Published on: December 16, 2016

Direct Protein Delivery to Mammalian Cells Using Cell-permeable Cys2-His2 Zinc-finger Domains

Direct Protein Delivery to Mammalian Cells Using Cell-permeable Cys2-His2 Zinc-finger Domains

Published on: March 25, 2015

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Area of Science:

Biotechnology
Nanomedicine
Molecular Biology

Background:

Traditional gene therapy vectors (viral and synthetic) face challenges with immunogenicity and biocompatibility.
Developing safe and efficient non-viral delivery systems is crucial for advancing gene therapy.

Purpose of the Study:

To review self-assembling short peptides as a next-generation gene delivery platform.
To elucidate peptide-nucleic acid co-assembly, design strategies, and nanocarrier barrier navigation.
To highlight applications in mRNA vaccines and CRISPR/Cas9 gene editing.

Main Methods:

Systematic review of fundamental chemistry, design strategies, and clinical applications of peptide-based gene delivery.
Analysis of supramolecular interactions and mechanisms of peptide-nucleic acid co-assembly.
Evaluation of nanocarrier performance in overcoming physiological and intracellular barriers.

Main Results:

Self-assembling peptides provide a programmable and biocompatible non-viral gene delivery platform.
Sequence engineering and environmental responsiveness enable optimized nanomorphology formation.
Peptide nanocarriers demonstrate potential in mRNA vaccine delivery and CRISPR/Cas9 gene editing.

Conclusions:

Self-assembling peptides represent a promising platform for overcoming gene therapy delivery bottlenecks.
Future directions include multifunctional integration and stimuli-responsive designs for enhanced clinical translation.
Further research is needed to address current obstacles for widespread clinical adoption.