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Epithelial Integrins Coordinate Cellular Crosstalk Through the Regulation of Cytokines During Tissue Remodeling
Jacob Snyder1, Sanjana Dhulipalla1,2, Whitney M Longmate1,2
1Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY 12208, USA.
Abstract:
Integrins are obligate αβ heterodimeric receptors that mediate cell-extracellular matrix interactions and exhibit bidirectional signal transduction across the plasma membrane. This integrin-mediated signal transduction regulates the expression of genes, a subset of which encode cytokines-small, secreted proteins that exhibit cell-cell communication in an autocrine or paracrine manner to regulate cell survival, proliferation, migration, ECM remodeling, and the immune response. This review examines epithelial integrins in the regulation of paracrine-acting cytokines that crosstalk to immune and stromal cells to coordinate normal and pathological tissue remodeling. Contexts explored include wound repair, fibrosis, and cancer.
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