Potential Applications of Genome-Wide Association Studies in Establishing Climate Resilience in Livestock: A...

Given livestock's crucial role in global food security and economic stability, the alarming threat of climate change calls for the implementation of effective mitigation strategies for climate-resilient livestock production. Management and nutritional strategies offer temporary relief, whereas genetic approaches represent a permanent solution. The role of genetic tools in enabling the development of climate-resilient livestock breeds is widely recognized. Genetic tools like microarrays, RNA-seq, omics, and GWAS can improve the understanding of livestock's climate adaptability at a molecular level. These tools facilitate the identification of biomarkers for thermo-tolerance, bordering on climate-resilient livestock breeding. Among them, studies employing genome-wide association studies (GWAS) have increased in recent years. GWAS have the potential to improve the genetic basis of thermo-tolerance in heat-stressed livestock populations. GWAS have been used to identify candidate genes for complex and economically important traits in livestock. These include growth, reproduction, disease resistance, milk, meat, and wool production traits under heat stress conditions. This makes GWAS a useful tool for identifying biomarkers that can be incorporated in breeding programs through marker-assisted selection (MAS). The integration of these potential biomarkers into selection and breeding programs would allow GWAS to substantially refine breeding strategies, thereby advancing the climate-resilient potential and sustainability of the livestock sector. Furthermore, GWAS, when utilized along with emerging technologies like Artificial Intelligence (AI), machine learning (ML), and deep learning (DL) for genomic prediction, can predict genetic aspects of livestock adaptation more efficiently and precisely. Thus, future studies should focus on integrated modeling approaches for improving the climate resilience of livestock without jeopardizing their production potential. Such an effort will contribute to sustainable livestock production as well as ensure food security for the growing human population amid changing climate conditions.