Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

3.0K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ethical Challenges and Governance Strategies for Microphysiological Systems Technology.

Biology·2026
Same author

Treatment with the Nox1/4 inhibitor Setanaxib ameliorates cardiac function in mouse models of Duchenne muscular dystrophy.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Self-assembled hierarchically porous composite film with ultrahigh MIL-101 loading for efficient atmospheric water harvesting.

Journal of colloid and interface science·2026
Same author

Triazine and other herbicides in sediments of lower Laurentian Great Lakes - pre- and post-depositional mobility and in-situ degradation.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Dissecting Immune Cell Ferroptosis via Single-Cell Multi-Omics Identifies RPL8 as a Potential Therapeutic Target for Depression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Stimulus-responsive metal-phenolic network nanomaterials for treating bacterial infections.

Nanotechnology·2026

Related Experiment Video

Updated: May 5, 2026

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.8K

Construction Strategies and Advances in Bone Marrow Microphysiological Systems.

Tian Lin1,2, Haodong Zhong1,2, Qianyi Niu1,3

  • 1National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, Beijing 102600, China.

International Journal of Molecular Sciences
|May 4, 2026
PubMed
Summary

Microphysiological systems (MPS) reconstruct the bone marrow niche for better hematopoietic stem cell (HSC) research. These advanced models improve understanding of blood formation, disease, and drug toxicity.

Keywords:
bone marrowhematopoietic stem cellmicrophysiological systemorgan-on-a-chiporganoid

More Related Videos

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

4.3K
Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
10:32

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

4.0K

Related Experiment Videos

Last Updated: May 5, 2026

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.8K
A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

4.3K
Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
10:32

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

4.0K

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Stem Cell Biology

Background:

  • The bone marrow niche is crucial for hematopoiesis but difficult to study using traditional methods.
  • Existing 2D cultures and animal models lack the complexity of the native bone marrow microenvironment.
  • This limits research into hematopoietic regulation, disease pathogenesis, and drug effects.

Purpose of the Study:

  • To review current strategies for engineering bone marrow microphysiological systems (MPS).
  • To highlight the importance of cellular components, biomaterials, vascularization, and perfusion in biomimetic bone marrow models.
  • To discuss advanced models for vascular niches, bone tissue, and metastasis.

Main Methods:

  • Systematic review of literature on bone marrow MPS construction.
  • Focus on three-dimensional organoids and microfluidic "on-a-chip" platforms.
  • Analysis of key engineering aspects: cellular composition, scaffolds, vascular networks, and perfusion.

Main Results:

  • Bone marrow MPS offer improved recapitulation of the native hematopoietic microenvironment.
  • These systems integrate cellular, material, and architectural elements for biomimicry.
  • Advanced models are being developed for complex biological scenarios like vascularization and metastasis.

Conclusions:

  • Bone marrow MPS provide a physiologically relevant in vitro platform for hematopoietic research.
  • These models enhance disease modeling and drug evaluation.
  • They support advancements in precision and regenerative medicine.