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Related Experiment Video

Updated: May 5, 2026

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
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Deciphering 6-mer Spectra Distribution Rules in Coronavirus Genomes: Application to Comparative Genomic Analysis.

Zhenhua Yang1,2, Hong Li3, Xiaolong Li4

  • 1School of Economics and Management, Inner Mongolia University of Science & Technology, Baotou 014010, China.

International Journal of Molecular Sciences
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

Comparative genomic analysis reveals coronaviruses primarily use a CG-specific selection mode. This finding identifies CG1 6-mers as key to coronavirus evolution and aids in accurate phylogenetic relationship inference.

Keywords:
CG-specific selection modecoronavirusesdistribution rules of 6-mer spectraphylogenetic relationshipsthe whole-genome level

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Area of Science:

  • Genomics
  • Virology
  • Evolutionary Biology

Background:

  • Coronaviruses, including SARS-CoV-2, exhibit rapid mutation and high transmissibility, necessitating genomic studies for understanding evolution and developing therapeutics.
  • Previous research identified both CG and TA-specific selection modes in genome sequences across diverse species.

Purpose of the Study:

  • To investigate specific selection modes within coronavirus genomes.
  • To identify fundamental genomic subsets driving coronavirus evolution.
  • To establish a theoretical framework for whole-genome phylogenetic analysis.

Main Methods:

  • Analysis of 32 XYi 6-mer subset spectra in coronavirus genomes.
  • Examination of intrinsic distribution rules and selection modes.
  • Construction of phylogenetic relationships using identified genomic subsets for coronaviruses and SARS-CoV-2 variants.

Main Results:

  • Coronavirus genomes exclusively exhibit the CG-specific selection mode, with no evidence of TA-specific selection.
  • CG1 6-mers were identified as the fundamental subset underlying coronavirus genome evolution.
  • Phylogenetic relationships constructed using the CG1 subset showed closer alignment with established knowledge.

Conclusions:

  • The CG-specific selection mode is dominant in coronavirus genome evolution.
  • CG1 6-mers provide a robust basis for understanding coronavirus evolutionary mechanisms.
  • This study offers a novel theoretical framework for whole-genome level phylogenetic inference in coronaviruses.