Exploring the Senotherapeutic Potential of Polyphenols in Aging and Disease: A Literature Review

Area of Science:

• Gerontology and cellular biology
• Nutritional science and pharmacology

Background:

• Aging increases the risk of age-related diseases (ARDs), posing a global health challenge.
• Cellular senescence, marked by cell cycle arrest and a senescence-associated secretory phenotype (SASP), is a critical aging mechanism and therapeutic target.
• Dietary compounds fisetin and quercetin are being investigated for their senolytic and senomorphic properties.

Purpose of the Study:

• To review existing evidence on fisetin and quercetin's effects on senescence and SASP.
• To explore their potential in animal models and human studies related to aging and ARDs.
• To identify factors influencing the clinical translation of these nutrients.

Main Methods:

• Narrative literature review of studies on fisetin and quercetin.
• Analysis of data from animal models of aging and progeria.
• Examination of human interventional studies in geriatric syndromes and ARDs.

Main Results:

• Fisetin and quercetin demonstrate potential in modulating senescence and SASP biomarkers.
• Evidence from animal and human studies suggests therapeutic benefits.
• The review highlights the need to overcome barriers for clinical application.

Conclusions:

• Fisetin and quercetin show promise as senolytics and senomorphics for managing aging and ARDs.
• Further research and clinical translation are warranted to harness their full therapeutic potential.
• Understanding senescence mechanisms is key to developing effective interventions.