Posttraumatic Stress Disorder and Handgrip Strength Among World Trade Center Firefighters and Emergency Medical...

Posttraumatic stress disorder (PTSD) has been linked to impaired physical function, which in turn predicts falls, morbidity, and mortality. However, few studies have used objective measures such as handgrip strength to assess physical function. In this cross-sectional study, we investigated associations of average PTSD symptom severity and symptom domain severity with measures of maximum handgrip strength and handgrip asymmetry from 11/2021-12/2023, among 381 male firefighters and emergency medical responders who responded to the World Trade Center disaster, using covariate-adjusted linear regression models. PTSD was diagnosed using the Structured Clinical Interview for the DSM-5 in 17% of responders. Greater overall PTSD average symptom severity was associated with weaker maximum handgrip strength (β = -4.43 lbs; 95%; CI: -8.77, -0.09; p = 0.045). Higher re-experiencing symptom severity was associated with weaker maximum handgrip strength (β = -4.17 lbs; 95% CI: -8.13, -0.22; p = 0.039). Avoidance symptoms were associated with weaker handgrip strength in adjusted models (β = -4.14 lbs; 95% CI: -7.56, -0.73; p = 0.018), and associated with a larger negative difference assessing for hand asymmetry (β = -2.20 lbs; 95% CI: -4.18, -0.22; p = 0.029). Findings suggest that PTSD may contribute to long-term physical decline, even in populations with high baseline fitness.