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Updated: May 5, 2026
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A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
Published on: April 19, 2019
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Exercise-Based Cardiac Rehabilitation for Peripheral Artery Disease
Francesco Giallauria1, Mario Pacileo2, Gianluigi Cuomo3
1Department of Translational Medical Sciences, Federico II University of Naples, via S. Pansini 5, 80131 Naples, Italy.
Journal of Clinical Medicine
|May 4, 2026
Summary
Supervised exercise therapy (SET) is a key treatment for peripheral artery disease (PAD), improving walking ability and reducing health risks. This review covers SET
Area of Science:
- Cardiovascular Medicine
- Exercise Physiology
- Rehabilitation Science
Background:
- Peripheral artery disease (PAD) affects over 100 million adults globally, causing significant functional decline and increasing risks of cardiovascular events and mortality.
- PAD is a widespread atherosclerotic condition linked to reduced quality of life and severe health complications.
- Exercise therapy is a primary, guideline-recommended treatment for PAD, enhancing patient outcomes and secondary prevention.
Purpose of the Study:
- To review the mechanisms of exercise therapy in PAD.
- To compare the effectiveness and safety of various exercise models, including supervised, home-based, and hybrid programs.
- To examine implementation strategies and identify research gaps for PAD exercise therapy.
Main Methods:
- Systematic review and synthesis of current literature on exercise therapy for PAD.
- Analysis of mechanistic studies focusing on endothelial, angiogenic, metabolic, and autonomic functions.
- Comparative appraisal of supervised exercise therapy (SET), home-based programs, and alternative interventions.
Main Results:
- Exercise therapy, particularly SET, demonstrably improves walking performance and patient-reported outcomes in PAD.
- Mechanistic insights reveal benefits in endothelial function, angiogenesis, metabolism, and autonomic regulation.
- Various implementation models show promise, with SET often considered the gold standard.
Conclusions:
- Supervised exercise therapy is a cornerstone of PAD management, offering significant functional and prognostic benefits.
- Understanding the mechanisms and comparative effectiveness of different exercise modalities is crucial for optimizing patient care.
- Addressing policy and research gaps is essential for broader implementation and improved outcomes in PAD patients.
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