Evaluating Large Language Models for Food Supplement Development: A Case Study in Glycemic Control

Background/Objectives: The rapidly expanding landscape of digital technologies is transforming innovation processes across industries, and the food sector is increasingly encouraged to adopt novel tools that can enhance development workflows and support competitive positioning. In the context of Industry 4.0, it is particularly important to examine open innovation approaches that may increase the efficiency of engineers and researchers involved in the research and development of food supplements. Such approaches enable broader access to relevant scientific information, including new bioactive ingredient research and their physiological implications, potentially contributing to the development of better-informed and higher-quality products. Methods: In the present study, we evaluated the deep research capabilities of several popular large language models to assess their suitability for supporting the conceptual design of a blood glucose-optimizing food supplement intended for prediabetes management. The comparative analysis focused on the level of detail in the outputs generated by each model, the robustness of the conclusions drawn, and the capacity to produce formulation-oriented recommendations grounded in scientific literature and regulatory frameworks. Our evaluation was primarily qualitative and subjective, highlighting both the potential and limitations of these models. Moreover, the study outlines a forward-looking concept for product validation using wearable smart devices and medically certified wearable devices with continuous biometric monitoring, which could provide an innovative avenue for assessing supplement efficacy. Results: The findings indicate that large language models can support the collection, organization, and preliminary interpretation of complex scientific information. Conclusions: Nevertheless, expert input remains essential for accurate evaluation, scientific validation, and regulatory compliance, as these models cannot yet replace domain expertise or rigorous experimentation in food supplement development.