Breeding Climate-Resilient Soybeans for 2050 and Beyond: Leveraging Novel Technologies to Mitigate Yield Stagnation...

Soybean is a vital crop supporting global food, feed, and biofuel production. Soybean yields have surged, with record yields reaching 14,678 kg/ha^-1, though average farm yields remain stagnant at 2770-2790 kg ha^-1. The persistent yield gaps leave 44% of potential production unrealized due to climate change, threatening food security. To meet future caloric demands, which are projected to rise by 46.8% by 2050, soybean breeding must prioritize climate-resilient, high-yielding varieties with minimal ecological footprints. In this comprehensive and in-depth review, we synthesized existing literature and Google Patents and reviewed the multifaceted impacts of climate-change driven eCO₂ and stresses (heat, drought, flooding, salinity, and pathogens), revealing non-linear interactions where eCO₂ may not compensate yield losses under combined stresses. We then highlight key strategies for soybean breeding under climate-change scenario. To this regard, we provide a detailed trait-by-trait breeding roadmap covering seed number, seed size, seed weight, protein-oil balance and their metabolic trade-offs, above and below ground plant architecture, nitrogen fixation and nodulation dynamics, root system architecture, water use efficiency, canopy architecture, flowering time regulation, early maturity etc., in light of specific genes and validated strategies. We explicitly discuss the novel strategies including deeper understanding of traits, abiotic stress physiology, changing pathogen dynamics, phenomics, (multi-)omics, machine learning, and modern biotechnological techniques for developing future soybean varieties. We provide a future roadmap prioritizing specific actions, including engineering climate-resilient ideotypes through gene stacking, optimizing nitrogen fixation and nutrition under stresses leveraging omics data, pan-genome, wild soybean, speeding breeding hubs, and participatory farmer-network validation, while redefining the future soybean breeder would be a hybrid orchestrator of data and dirt. This review establishes a foundational framework for translating climate-adaptive morphological, biochemical, physiological, omics, agronomic, phenomics, and biotechnological insights into actionable breeding strategies, thereby guiding policy-driven investment in soybean improvement programs targeting 2050 and beyond.