Related Experiment Video
Updated: May 5, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Inappropriate Antimicrobial Dosing in Regard to Renal Function in a Tertiary Hospital in Greece-A Single-Center Point
Petros Ioannou1,2, Andria Papazachariou2, Stamatis Karakonstantis1,2
1School of Medicine, University of Crete, 71003 Heraklion, Greece.
Inappropriate antimicrobial dosing for kidney function is common in hospitals, affecting 15.7% of patients. Older patients and those with impaired renal function are most at risk for dosing errors, highlighting a need for improved antimicrobial stewardship.
Area of Science:
- Pharmacology
- Nephrology
- Infectious Diseases
Background:
- Appropriate antimicrobial dosing adjusted for kidney function is crucial for treatment efficacy and preventing resistance.
- Despite guidelines and electronic systems, antimicrobial dosing errors in patients with impaired renal function are frequent.
Purpose of the Study:
- To evaluate the appropriateness of antimicrobial dosing in relation to renal function in hospitalized patients.
- To identify specific drugs and patient groups with higher rates of dosing errors.
Main Methods:
- A point-prevalence study was conducted in a tertiary-care hospital in Greece.
- Patient data, including renal parameters and antimicrobial prescriptions, were extracted from electronic medical records.
- Glomerular filtration rate (GFR) was estimated using the MDRD formula.
Main Results:
- 15.7% of 235 hospitalized patients received inappropriate antimicrobial doses based on renal function.
- Ceftazidime, cefuroxime, colistin, and acyclovir had high error rates; piperacillin/tazobactam had a lower rate but was frequently prescribed.
- Patients with dosing errors were older, had poorer renal function, and received more antimicrobials.
Conclusions:
- Inappropriate antimicrobial dosing is a significant issue in hospitalized patients, especially the elderly and those with renal impairment.
- Targeted antimicrobial stewardship strategies are needed to improve renal dose adjustments for specific drugs and patient populations.
- Enhancing prescribing safety and optimizing therapeutic outcomes requires focused interventions on common dosing errors.
More Related Videos
06:19Author Spotlight: Characterizing Airway Environments to Advance Model Systems and Antimicrobial Discovery in Cystic Fibrosis and Chronic Respiratory Infections
Published on: October 11, 2024
11:28A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
Published on: September 9, 2015
Related Concept Videos
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant
Pharmacokinetics in Pediatric Patients: Drug Excretion
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Acute Pyelonephritis II: Diagnostic Studies and Management