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Updated: May 5, 2026
Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
Prognostic Value of the CALLY Index in Predicting All-Cause Mortality After Transcatheter Aortic Valve Implantation:
Zeynep Esra Güner1, İsmail Balaban2, Mustafa Ferhat Keten2
1Department of Cardiology, Uzunköprü State Hospital, Edirne 22000, Turkey.
Insights
The C-reactive protein-albumin-lymphocyte (CALLY) index effectively predicts mortality in patients undergoing transcatheter aortic valve implantation (TAVI). A low CALLY index is an independent risk factor for death after TAVI.
Area of Science:
- Cardiology
- Biomarkers
- Prognostic Indicators
Background:
- Severe aortic stenosis necessitates transcatheter aortic valve implantation (TAVI).
- Accurate risk stratification is crucial for optimizing TAVI patient outcomes.
- Existing prognostic scores may require enhancement for this specific population.
Purpose of the Study:
- To evaluate the prognostic value of the C-reactive protein-albumin-lymphocyte (CALLY) index.
- To assess the CALLY index's ability to predict all-cause mortality post-TAVI.
- To compare the CALLY index with established prognostic scores in TAVI patients.
Main Methods:
- Retrospective single-center study of 303 patients undergoing TAVI.
- Baseline calculation of the CALLY index and other prognostic scores.
- Median follow-up of 21 months with all-cause mortality as the primary endpoint.
Main Results:
- The CALLY index showed the highest predictive performance for all-cause mortality (AUC = 0.698).
- A low CALLY index was an independent predictor of mortality (HR = 3.80).
- Worse survival was observed in the high-risk CALLY index group (log-rank p < 0.001).
Conclusions:
- The CALLY index is independently associated with mortality following TAVI.
- The CALLY index may serve as a valuable complementary biomarker for risk stratification.
- Further research can validate the CALLY index for routine clinical use in TAVI patients.
Abstract:
Background and Objectives: This study investigated the prognostic value of the C-reactive protein-albumin-lymphocyte (CALLY) index in predicting all-cause mortality among patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis. Materials and methods: This retrospective single-center study included 303 patients who underwent TAVI. The CALLY index and other established prognostic scores were calculated at baseline. Patients were followed for a median of 21 months. The primary endpoint was all-cause mortality. Results: A total of 60 patients (19.8%) died during follow-up. The CALLY index demonstrated the highest predictive performance for all-cause mortality, with an AUC of 0.698 (95% CI: 0.628-0.768, p < 0.001). In multivariate Cox regression, a low CALLY index remained an independent predictor of mortality (HR: 3.80, 95% CI: 2.03-7.11, p < 0.001), along with reduced LVEF, chronic kidney disease, and diabetes mellitus. Kaplan-Meier analysis further confirmed markedly worse survival in the high-risk group (log-rank p < 0.001). Conclusions: The CALLY index was independently associated with mortality after TAVI and may represent a complementary biomarker for risk stratification in this population.
