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Hemispheric Asymmetries in Bipolar Disorder: A Systematic Review.

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Summary

This review finds evidence of atypical brain asymmetry in bipolar disorder (BD), with mood states influencing hemispheric activation. Further research is needed for a complete understanding of hemispheric asymmetry in BD.

Keywords:
bipolar disorderbrain lateralizationcognitive functionemotional lateralizationhemispheric asymmetrymood disorders

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • Cerebral asymmetries and bipolar disorder (BD) are of significant research interest.
  • Investigating hemispheric asymmetry in BD is a relatively new but growing field.
  • Existing literature suggests potential links between BD and atypical brain asymmetry.

Purpose of the Study:

  • To systematically review and critically discuss evidence of hemispheric asymmetry in BD.
  • To examine brain anatomy, physiology, and neuropsychological function related to asymmetry in BD.
  • To test hypotheses of atypical cerebral asymmetry and mood-dependent hemispheric activation in BD.

Main Methods:

  • Systematic literature review following PRISMA 2020 guidelines.
  • Screening of research papers based on specific inclusion/exclusion criteria.
  • Risk of bias assessment using the Newcastle-Ottawa Scale (NOS).

Main Results:

  • 56 eligible papers were identified.
  • An emerging pattern of atypical hemispheric asymmetry in brain structure and function in BD was observed.
  • Depressive states linked to right hemisphere activation; manic states linked to left hemisphere activation.

Conclusions:

  • Findings support hypotheses of atypical asymmetry and mood-dependent activation in BD.
  • Results partially align with emotional laterality theories.
  • Contradictory findings necessitate further extensive research for comprehensive understanding.