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Solid Pro-Nano Lipid Oral Formulations for Cannabidiol (CBD).
Awanish Kumar1, Ayala Bar-Hai1, Muhammad AbdEl-Haq1
1Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Pharmaceutics
|May 4, 2026
Summary
New solid pro-nano lipid (SPNL) formulations enhance oral cannabidiol (CBD) bioavailability in rats. These stable, solvent-free systems offer a safer alternative for delivering lipophilic drugs orally.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Development of novel solid pro-nano lipid (SPNL) oral formulations.
- Investigation focused on enhancing oral bioavailability of cannabidiol (CBD).
Purpose of the Study:
- To prepare and characterize SPNL formulations for oral drug delivery.
- To evaluate the pharmacokinetic performance of SPNL and LPNL formulations in rats.
- To assess the stability of these novel formulations.
Main Methods:
- Preparation of SPNL formulations containing up to 40% w/w CBD.
- Characterization of particle size upon dispersion in aqueous media (<200 nm).
- Pharmacokinetic studies in Wistar rats following oral administration of SPNL and LPNL.
- Stability testing of formulations at room temperature for 3 months.
Main Results:
- SPNL and LPNL formulations demonstrated rapid CBD absorption and high Cmax values in rats.
- Formulations exhibited stability at room temperature for at least 3 months.
- Lesser CBD stability observed with mesoporous silica particles (Neusilin US2, SYLOID 244 FP).
Conclusions:
- SPNL formulations are solvent-free, offering a safer alternative to traditional SNEDDS systems.
- These solid lipid-based formulations show potential for delivering other lipophilic drugs.
- The developed formulations provide enhanced oral bioavailability for CBD.
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