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CBD Promotes Structural and Functional Epithelial Restoration and Alleviates Inflammation in a Mouse Model of
Dominika Peskar1, Mojca Kerec Kos2, Špela Tavčar1
1Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
Pharmaceutics
|May 4, 2026
Summary
Cannabidiol (CBD) may help treat interstitial cystitis (IC). CBD treatment restored bladder structure, reduced inflammation, and improved animal well-being in a mouse model of IC.
Area of Science:
- Urology
- Pharmacology
- Cannabinoid Research
Background:
- Interstitial cystitis (IC) is a chronic bladder inflammation with unknown causes, managed symptomatically.
- Cannabidiol (CBD) offers anti-inflammatory and antioxidant benefits without psychoactivity.
- The effects of CBD on the urinary bladder and animal well-being in IC models are not well-understood.
Purpose of the Study:
- To investigate the therapeutic potential of CBD in a cyclophosphamide (CYP)-induced mouse model of IC.
- To evaluate CBD's impact on bladder structure, function, inflammation, and animal behavior.
Main Methods:
- Utilized a cyclophosphamide (CYP)-induced mouse model of IC.
- Administered CBD intraperitoneally and assessed effects via microscopy, immunolabeling, qPCR, TEER measurements, and behavioral tests.
Main Results:
- CBD treatment aided urothelial structure restoration and blood-urine barrier integrity.
- CBD demonstrated anti-inflammatory effects, reducing bladder edema and inflammatory cell infiltration.
- Increased burrowing activity in CBD-treated mice indicated improved overall well-being.
Conclusions:
- CBD shows promise as a beneficial agent for inflamed bladders in IC.
- CBD may serve as a potential adjunct therapy for future interstitial cystitis treatment.
Keywords:
cannabidiolcannabinoid receptorsinflammationinterstitial cystitispermeability barrierurinary bladderurotheliumMore Related Videos
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