Changes in cannabis potency and cannabis-related psychiatric harms: a 23-year ecological study in Denmark

In recent decades, the potency of cannabis resin increased globally, raising concerns, as higher potency has been associated with increased risk of psychiatric harms at the individual level. The aim here was to examine whether changes over time in the potency of seized cannabis resin samples were associated with psychiatric harms at the population level.

Data on ∆-9-tetrahydrocannabinol (THC) concentration in seized cannabis resin were obtained from forensic departments in Denmark (2000-2022), the country reporting the highest potency in Europe. Data on admissions to cannabis treatment, incidence of cannabis-induced psychosis, and dual diagnosis (schizophrenia and cannabis use disorder) were obtained from national registers. Time-dependent associations between potency and the outcomes were examined with mixed-effects linear regression models and associations across age and sex were explored. Candidate time lags were 0-10 years.

THC concentration increased almost fourfold: mean 8.3-31.2% from 2000 to 2022. In fully adjusted models, THC was positively associated with first-time cannabis treatment entry at lags of 0-6, strongest at year 0 (p < 0.0001); incidence of cannabis-induced psychosis at lags of 0-4, strongest at year 0 (p < 0.0001); and incidence of dual diagnosis at lags of 0-1, strongest at year 0 (p < 0.01). No positive associations were found in unadjusted models. Subgroup analyses indicated associations in older patients and women.

Potency of seized cannabis resin increased almost fourfold from 2000 to 2022. Changes in cannabis potency were positively associated with psychiatric harms at the population level across all outcomes.