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Updated: May 5, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Systemic allergic contact dermatitis to nickel presenting predominantly as severe hand dermatitis, successfully
Parisa Mirzajani1, Joel G DeKoven2, Anastasia Shamsuyarova1
1Thunder Bay Regional Health Science Centre, Northern Ontario School of Medicine, ON, Canada.
Abstract:
Systemic allergic contact dermatitis to nickel is a challenging condition often presenting as severe hand dermatitis. This case report details the clinical course of a 33-year-old male truck driver with severe hand dermatitis secondary to systemic allergic contact dermatitis to nickel. Despite significant improvement with avoidance, the patient experienced recurrent flares due to ongoing accidental nickel exposure. Upadacitinib provided an effective salvage strategy. The case underlines challenges of managing systemic allergic contact dermatitis.
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