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The In ovo CAM-assay as a Xenograft Model for Sarcoma
Published on: July 17, 2013
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CEACAM1 Is Associated With an Immune-Activated Tumor Microenvironment and Therapeutic Stratification in Sarcoma
Ziqi Cao1, Minjue Shan2, Yadong Guo3
1Department of Surgery, Heilongjiang University of Chinese Medicine Affiliated Second Hospital, Harbin, 150001, China.
International Journal of Genomics
|May 4, 2026
Summary
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a key player in sarcoma immunity. High CEACAM1 expression predicts better outcomes and suggests response to immunotherapy in sarcoma patients.
Area of Science:
- Oncology
- Immunology
- Genomics
Background:
- Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) has a dual role in immune modulation across cancers.
- Its specific role in sarcoma (SARC) is not well understood.
Purpose of the Study:
- To comprehensively analyze CEACAM1's biological significance and clinical relevance in sarcoma.
- To investigate CEACAM1's prognostic value, immune microenvironment associations, and therapeutic implications in SARC.
Main Methods:
- Integrated multiomics analysis using TCGA, GTEx, CPTAC data.
- Evaluated transcriptomic, genomic, epigenetic, immunological, and pharmacogenomic data.
- Assessed CEACAM1 expression, prognostic value, immune infiltration, pathway associations, and drug sensitivity.
Main Results:
- Elevated CEACAM1 expression in SARC correlates with favorable clinical outcomes and an immune-enriched tumor microenvironment.
- High CEACAM1 is linked to increased CD8+ T-cell infiltration, interferon-γ signaling, and immune effector gene upregulation.
- CEACAM1 expression indicates reduced sensitivity to chemotherapy but enrichment of immunotherapy-responsive signatures.
Conclusions:
- CEACAM1 may serve as a biomarker for immune activation and therapeutic stratification in SARC.
- CEACAM1 warrants further investigation as a predictive indicator and immunotherapy target in mesenchymal malignancies.
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