Related Experiment Video
Updated: May 5, 2026

Establishment of Acute Pontine Infarction in Rats by Electrical Stimulation
Published on: August 27, 2020
Central Pontine Myelinolysis Leading to an Intensive Care Unit Admission
Miguel Santos1, Ana Cunha1, Ana Alburquerque1
1Intensive Care Unit, Unidade Local de Saúde da Região de Leiria, Leiria, PRT.
Abstract:
Osmotic demyelination syndrome (ODS) is a rare and serious clinical syndrome that has been associated with rapid correction of severe hyponatremia. ODS can evolve to central pontine myelinolysis (CPM), in which demyelination occurs in the pontine region, and less commonly extrapontine myelinolysis (EPM), involving other brain regions. We present the case of a 52-year-old alcoholic man admitted for community-acquired pneumonia who developed CPM following rapid correction of severe hyponatremia. This case highlights the importance of careful correction of sodium levels, particularly in high-risk patients.
Related Concept Videos
Bacterial Meningitis I: Introduction
Secondary Spinal Cord Injury llI: Pathophysiology
Brain Abscess l: Introduction
Acute Respiratory Failure-III
Acute Coronary Syndrome IV: Interprofessional Care
Hepatic Encephalopathy

