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Updated: May 5, 2026
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Pd(II)-Catalyzed C-H Activation/O‑Annulation toward Succinimide-Embedded Tetracyclic Pyranonaphthoquinones and Their
Eswaran Kamaraj1,2, Amrendra Kumar1, Sonaimuthu Mohandoss1
1School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Abstract:
A Pd-(II)-catalyzed cascade C-H activation/O-annulation strategy is developed for the efficient synthesis of succinimide-integrated tetracyclic pyranonaphthoquinones using 3-aryl-2-hydroxy naphthoquinones with maleimides or itaconimides as substrates. This methodology provides a fast and efficient approach to prepare diverse tetracyclic pyranonaphthoquinones featuring spirosuccinimides or succinimide motifs via [5 + 1] cycloaddition. Notably, one of the synthesized compounds exhibited high sensitivity and selectivity as a fluorescent chemosensor for Fe3+ ions, achieving a low detection limit of 30.07 × 10-9 M.
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