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NMR Spectrometers: Resolution and Error Correction

NMR Spectrometers: Resolution and Error Correction

When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...

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Updated: Jun 22, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Rapid Parallel Magnetic Resonance Relaxometry on Multiwell Plates with a Benchtop Scanner.

Hans Gaensbauer^1,2,3, Yanmeng Yang², Daniel Roxby^2,3

¹Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

|May 4, 2026

Summary

This summary is machine-generated.

Nuclear magnetic resonance relaxometry is now faster and non-destructive. A new low-cost system enables rapid, multi-well measurements for drug screening and cell culture development.

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Area of Science:

Biophysics
Analytical Chemistry
Medical Diagnostics

Background:

Nuclear magnetic resonance (NMR) relaxometry offers valuable applications in medicine, biology, and chemistry.
Current relaxometry methods are often slow, destructive, and require large sample volumes.
These limitations hinder applications like drug screening and cell culture development.

Purpose of the Study:

To develop and demonstrate a low-cost, benchtop system for rapid, non-destructive NMR relaxometry.
To enable parallel measurements on multiple samples simultaneously.
To overcome the limitations of traditional relaxometry workflows.

Main Methods:

A novel low-cost benchtop NMR relaxometry system was designed and built.
The system performs measurements on 16 wells of a 96-well plate in a single run.
No sample preparation is required, allowing for non-destructive analysis.

Main Results:

The system enables rapid, non-destructive scanning of multiple samples.
Demonstrated parallel measurement capabilities for applications like iron measurement.
Successfully performed relaxometry on multiple groups without sample preparation.

Conclusions:

The developed multiwell NMR relaxometry system significantly improves workflow efficiency.
This technology facilitates broader applications of relaxometry in drug screening and cell culture.
The system offers a cost-effective and rapid solution for parallel relaxometry measurements.