Rapid Parallel Magnetic Resonance Relaxometry on Multiwell Plates with a Benchtop Scanner

Nuclear magnetic resonance relaxometry measurements have a diverse array of applications in medicine, biology, and chemistry, and they are valuable for monitoring cell cultures, diagnosing diseases, and detecting defects in pharmaceutical products. However, relaxometry workflows typically require laborious procedures and large sample volumes, which are both slow and destructive. This makes it difficult to use relaxometry in applications such as drug screening and cell culture development, where it has significant potential to be useful. In this work, we describe and demonstrate a low-cost benchtop system that can perform relaxometry measurements on 16 wells of a 96-well culture plate in one shot, enabling rapid, nondestructive scanning of multiple groups without any sample preparation. We demonstrate the application of this multiwell scanner for iron measurement and parallel measurements.