Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integration of Metabolomics and Proteomics Reveals the Molecular Characterization of High-Altitude Hyperuricemia.

Journal of proteome research·2025
Same author

3-MA attenuates collagen-induced arthritis in vivo via anti-inflammatory effect and autophagy inhibition.

BMC musculoskeletal disorders·2025
Same author

Author Correction: π-HuB: the proteomic navigator of the human body.

Nature·2024
Same author

π-HuB: the proteomic navigator of the human body.

Nature·2024
Same author

RhoGDIβ inhibition via miR-200c/AUF1/SOX2/miR-137 axis contributed to lncRNA MEG3 downregulation-mediated malignant transformation of human bronchial epithelial cells.

Molecular carcinogenesis·2024
Same author

Correction to "Rapamycin Inhibits Osteoclastogenesis and Prevents LPS-Induced Alveolar Bone Loss by Oxidative Stress Suppression".

ACS omega·2023

Related Experiment Video

Updated: Jul 4, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

10.8K

ROS-Responsive Hydrogel Loaded with Antimicrobial Peptides Accelerated Infected Wound Healing.

Zefan Niu1,2, Yunzhe Li1,2, Qing Yuan1,2

  • 1Military Medical Sciences Academy, Tianjin 300050, China.

ACS Omega
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

This study developed a novel antibacterial hydrogel that effectively treats infected wounds. The ROS-responsive hydrogel promotes wound healing and blood vessel formation while reducing inflammation.

More Related Videos

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
10:49

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

4.1K
Fabrication and Surgical Application of Enriched Photo-crosslinked Gelatin–Riboflavin Hydrogels for Corneal Wound Repair in Rabbits
05:53

Fabrication and Surgical Application of Enriched Photo-crosslinked Gelatin–Riboflavin Hydrogels for Corneal Wound Repair in Rabbits

Published on: April 24, 2026

16

Related Experiment Videos

Last Updated: Jul 4, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

10.8K
Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
10:49

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

4.1K
Fabrication and Surgical Application of Enriched Photo-crosslinked Gelatin–Riboflavin Hydrogels for Corneal Wound Repair in Rabbits
05:53

Fabrication and Surgical Application of Enriched Photo-crosslinked Gelatin–Riboflavin Hydrogels for Corneal Wound Repair in Rabbits

Published on: April 24, 2026

16

Area of Science:

  • Biomaterials Science
  • Wound Healing Research
  • Antimicrobial Hydrogels

Background:

  • Skin injuries generate reactive oxygen species (ROS), impairing wound healing.
  • Bacterial infections exacerbate ROS production, damaging tissues and blood vessels.
  • Hyaluronic acid (HA) is a bioactive polymer frequently used in hydrogel formulations.

Purpose of the Study:

  • To synthesize a novel ROS-responsive, antibacterial hydrogel for infected wound treatment.
  • To evaluate the hydrogel's biocompatibility, antioxidant properties, and antimicrobial efficacy.
  • To assess the hydrogel's therapeutic potential in promoting infected wound healing and angiogenesis in vivo.

Main Methods:

  • Grafting HA onto phenylboronic acid and cross-linking with PVA via ROS-sensitive phenylboron ester bonds.
  • Incorporating antimicrobial peptide (AMP) into the hydrogel matrix.
  • Conducting in vitro biocompatibility, antioxidant assays, and bacterial inhibition tests (E. coli, S. aureus).
  • Performing in vivo studies on infected mouse wound models to evaluate healing, inflammation, and angiogenesis.

Main Results:

  • The synthesized hydrogel demonstrated excellent biocompatibility and antioxidant capacity.
  • Significant inhibition of both E. coli and S. aureus was observed.
  • In vivo studies showed accelerated healing of infected wounds in mice.
  • The hydrogel upregulated IL-6, TGF-β, CD31, and VEGF levels, promoting angiogenesis and reducing inflammation.

Conclusions:

  • The developed ROS-responsive antibacterial hydrogel is a promising therapeutic agent for infected wounds.
  • The hydrogel facilitates wound healing by modulating inflammatory responses and enhancing angiogenesis.
  • The study highlights the potential of functionalized HA-based hydrogels in regenerative medicine.