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Improved prostate diffusion imaging using deep learning denoising and phase correction with ultra-high-density coil

Sherry S Huang1, Xinzeng Wang2, Patricia Lan3

  • 1Research and Scientific Affairs, GE HealthCare, Rochester, MN, 55901, United States.

Radiology Advances
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

This study shows that a novel 50-channel pelvic coil combined with deep learning phase correction and denoising significantly improves prostate diffusion-weighted imaging (DWI) quality. Enhanced DWI quality aids in better identification of clinically significant prostate cancer.

Keywords:
deep-learning denoisingdeep-learning reconstructiondiffusion weighted imagingflexible-coil-arrayphase correctionprostate MRI

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Medical Imaging
  • Radiology

Background:

  • Diffusion-weighted imaging (DWI) is crucial for identifying clinically significant prostate cancer.
  • High b-value DWI is limited by low signal-to-noise ratio (SNR), high noise, and susceptibility artifacts.

Purpose of the Study:

  • To assess the feasibility of enhancing DWI quality using a novel 50-channel pelvic coil.
  • To evaluate the combined use of deep learning (DL)-based phase correction and DL-denoising algorithms for DWI improvement.

Main Methods:

  • Prospective study of 24 men undergoing prostate MRI.
  • DWI acquisition using a prototype 50-channel coil and standard phased array coil.
  • Reconstruction with vendor's DL denoising (ARDL) and an investigational DL Phase Correction + ARDL (DLPC+ARDL) algorithm.
  • Qualitative scoring by two readers and quantitative SNR/CNR measurements.

Main Results:

  • The 50-channel coil with DLPC+ARDL achieved significantly higher SNR (99.70 ± 28.50) and CNR (91.68 ± 44.39) compared to other methods (P < .0001).
  • DLPC+ARDL improved prostate border definition, zone distinction, lesion conspicuity, and confidence in detecting extraprostatic extension.
  • Inter-reader agreement was fair for acquired DWI (κ=0.34) and lower for synthetic DWI (κ=0.19).

Conclusions:

  • The 50-channel pelvic coil combined with DLPC + ARDL reconstruction yields superior DWI image quality.
  • This approach significantly outperforms ARDL alone and standard 30-channel coil imaging.
  • Improved DWI quality has implications for more accurate prostate cancer detection and characterization.