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Updated: May 5, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

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Motif-Hi-C: A motif-based framework for rapid quality control of Hi-C data

Dashuai Kong1,2, Yuhui Wang3, Yueting Tang2

  • 1State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.

Abiotech
|May 4, 2026
PubMed
Summary

Motif-Hi-C improves three-dimensional (3D) genome analysis by using sequence signatures for rapid, reliable quality control. This computational framework enhances processing speed and accuracy for Hi-C data, benefiting large-scale genomics studies.

Keywords:
Batch-processing classificationChimeric-sequence-based quality controlHi-C data assessmentLigation-motif signatureMotif-Hi-CTime-accuracy tradeoff

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