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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Related Experiment Video

Updated: May 5, 2026

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Changes in Subcortical Structure Volumes Associated With Obesity.

Sultan Alamri1

  • 1Department of Radiological Sciences, College of Applied Medical Sciences, Taif University, Taif, SAU.

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Summary
This summary is machine-generated.

Obesity is linked to brain changes. Obese men showed larger gray matter volumes in the amygdala and thalamus, suggesting structural brain alterations in obesity.

Keywords:
freesurferimagingmrineuroimaging techniquesobesity

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Medical Research

Background:

  • Obesity is increasingly associated with structural brain alterations.
  • Subcortical gray matter regions are particularly implicated in these changes.

Purpose of the Study:

  • To investigate volumetric differences in subcortical brain structures between obese and normal-weight individuals.
  • To determine if obesity correlates with measurable changes in brain structure.

Main Methods:

  • Cross-sectional observational study involving 38 normal-weight and 8 obese men.
  • High-resolution T1-weighted MRI scans analyzed using FreeSurfer and ITK-SNAP for automated and manual segmentation.
  • Statistical comparisons of subcortical gray matter volumes between the two groups.

Main Results:

  • Obese individuals exhibited significantly larger gray matter volumes in the right amygdala and left thalamus.
  • Near-significant increases in gray matter volume were observed in the bilateral hippocampus and putamen.
  • Manual segmentation confirmed significant enlargement of the amygdala and caudate in obese participants.

Conclusions:

  • Obesity is associated with subtle yet consistent volumetric expansion in key subcortical brain regions.
  • These structural differences may have implications for cognitive and behavioral functions.
  • Further research is required to elucidate the underlying mechanisms and functional consequences of these obesity-related brain changes.