Related Experiment Video

Updated: May 5, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.8K

Depressive Symptom Burden and Its Relationship With Health-Related Quality of Life in Patients on Peritoneal Dialysis

Cecilia Salud-Gutiérrez1, Ulises Avedaño-Ignacio1, Merhary B Meza-Matus1

  • 1Family Medicine, Hospital General de Zona No. 2 con Medicina Familiar, Instituto Mexicano del Seguro Social, Salina Cruz, MEX.

Cureus
|May 4, 2026
PubMed

Insights

Depressive symptoms significantly impact health-related quality of life (HRQoL) in patients undergoing peritoneal dialysis. Addressing depression is crucial for improving patient outcomes in chronic kidney disease care.

Area of Science:

  • Nephrology
  • Psychiatry
  • Public Health

Background:

  • Chronic kidney disease (CKD) requiring peritoneal dialysis presents significant patient burdens.
  • Depressive symptoms are a key non-biological factor affecting patient outcomes and quality of life.
  • The relationship between depression and HRQoL in peritoneal dialysis patients, especially in Latin America, requires further characterization.

Purpose of the Study:

  • To evaluate the relationship between depressive symptoms and health-related quality of life (HRQoL) in patients undergoing peritoneal dialysis.
  • To investigate this association within a Latin American population.

Main Methods:

  • An observational, cross-sectional study included 150 adult peritoneal dialysis patients.
  • Health-related quality of life (HRQoL) was measured using the KDQOL-36 instrument.
  • Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9).

Main Results:

  • A strong, statistically significant inverse relationship was found between depressive symptoms and HRQoL (rₛ = -0.771, p<0.001).
  • Increasing severity of depressive symptoms correlated with a progressive decline in quality of life scores.
  • Patients predominantly exhibited mild depressive symptoms, with a median PHQ-9 score of 7.

Conclusions:

  • Depressive symptoms are strongly associated with impaired HRQoL in peritoneal dialysis patients.
  • Routine mental health assessments and multidisciplinary interventions are vital in nephrology care.
  • Improving patient-centered outcomes necessitates addressing the mental health needs of CKD patients on dialysis.

Keywords:
chronic kidney diseasedepressiondepressive symptomshealth-related quality of lifekdqol-36peritoneal dialysisphq-9quality of life

More Related Videos

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice06:27

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Published on: July 20, 2022

2.9K
Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

15.0K

Related Concept Videos

Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
1.6K
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
2.1K
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
2.2K
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
1.3K
Peritoneal Dialysis I: Introduction and Procedure01:30

Peritoneal Dialysis I: Introduction and Procedure

Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
8.5K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K