Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Histone Modification02:32

Histone Modification

14.6K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
14.6K
Histone Modification02:32

Histone Modification

4.0K
4.0K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

8.1K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
8.1K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

1.5K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
1.5K
Histone Variants at the Centromere02:30

Histone Variants at the Centromere

4.0K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
4.0K
Human Genetics01:28

Human Genetics

2.0K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges and prospects for malaria elimination in the Greater Mekong Subregion.

Acta tropica·2011
Same author

[Optimization of extraction procedure of tongmai granules by orthogonal design with pharmacodynamic index].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2011
Same author

Determinants of postoperative corneal edema and impact on goldmann intraocular pressure.

Cornea·2011
Same author

Z-palatopharyngoplasty plus genioglossus advancement and hyoid suspension for obstructive sleep apnea hypopnea syndrome.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2011
Same author

Efficient and selective photodimerization of 2-naphthalenecarbonitrile mediated by cucurbit[8]uril in an aqueous solution.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2011
Same author

Quality assurance and quality improvement in U.S. clinical molecular genetic laboratories.

Current protocols in human genetics·2011

Related Experiment Video

Updated: May 5, 2026

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
08:33

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models

Published on: March 24, 2019

6.9K

Modifications on histone tails in psychiatric disorders.

Qiao Mao1, Zhixiong Luo2, Zongyang Yu3

  • 1Department of Psychosomatic Medicine, People's Hospital of Deyang City, Deyang, Sichuan 618000, China.

EC Psychology and Psychiatry
|May 4, 2026
PubMed
Summary

Histone tail modifications are linked to ten psychiatric disorders, with specific changes like H3K9ac and H3K4me3 being most common. Targeting these epigenetic marks offers potential new treatments for conditions like schizophrenia and Alzheimer's disease.

Keywords:
acetylationepigenetic regulationgene expressionhistone modificationhistone tailmethylationpsychiatric disorder

More Related Videos

Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
08:12

Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue

Published on: May 5, 2022

3.6K
Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue
09:43

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue

Published on: November 30, 2018

24.1K

Related Experiment Videos

Last Updated: May 5, 2026

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
08:33

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models

Published on: March 24, 2019

6.9K
Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
08:12

Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue

Published on: May 5, 2022

3.6K
Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue
09:43

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue

Published on: November 30, 2018

24.1K

Area of Science:

  • Epigenetics
  • Neuroscience
  • Biochemistry

Background:

  • Histone tails are crucial regulatory regions of chromatin.
  • Dysregulation of histone modifications is implicated in various diseases.
  • Understanding these roles in psychiatric disorders is vital for therapeutic development.

Purpose of the Study:

  • To comprehensively review histone tail features and their functions.
  • To systematically analyze the association between histone tail modifications and psychiatric disorders.
  • To identify key histone modifications and affected psychiatric conditions.

Main Methods:

  • Conducted a literature search of over 200 histone modifications and 20 psychiatric disorders.
  • Analyzed positive associations between specific histone tail modifications and psychiatric conditions.
  • Identified the most prevalent modifications and associated disorders.

Main Results:

  • 26 histone tail modifications positively correlate with ten psychiatric disorders.
  • H3 and H4 tails are most frequently modified, primarily at lysine residues.
  • H3K9ac, H3K4me3, H3K27ac, H3K9me2, and γH2AX are top modifications linked to psychiatric disorders.
  • Substance use disorders, Alzheimer's disease, major depressive disorder, schizophrenia, and autism spectrum disorders are the most studied.
  • 92% of studies focused on these top five disorders.

Conclusions:

  • Histone tail modifications play significant roles in the pathophysiology of psychiatric disorders.
  • Targeting histone modifications and epigenetic regulators presents a promising therapeutic avenue.
  • This research provides insights into molecular mechanisms underlying abnormal gene expression in psychiatric conditions.