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Updated: May 5, 2026

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Changes in aortic centerline length and curvature predict aortic diameter growth in chronic type B aortic dissection

Xue Liang1,2, Hai Dong1,2, Marc-Philipp H Schmid2

  • 1Division of Cardiothoracic Surgery, Carlyle Fraser Cardiothoracic Research Laboratory, Emory University School of Medicine, Atlanta, Ga.

JTCVS Open
|May 4, 2026
PubMed

Insights

In chronic type B aortic dissection (TBAD), aortic centerline length and curvature changes inversely correlate with diameter growth. These geometric changes may serve as better predictors for aortic diameter growth than diameter measurements alone.

Area of Science:

  • Cardiovascular Surgery
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Aortic diameter is the primary metric for surgical intervention in chronic type B aortic dissection (TBAD).
  • Understanding factors influencing aortic diameter growth is crucial for patient management.

Purpose of the Study:

  • To investigate the correlation between aortic diameter growth and changes in aortic centerline length (CL) and centerline curvature (CC) in chronic TBAD.
  • To determine if CL and CC changes are better predictors of diameter growth than diameter changes alone.

Main Methods:

  • Retrospective analysis of 88 CT scans from 35 patients with chronic TBAD.
  • 3D reconstruction of aortic geometry and centerlines.
  • Linear regression analysis to assess the relationship between diameter growth rate and CL/CC growth rate.

Main Results:

  • CL and CC growth rates showed a significant inverse correlation with mean and maximum diameter growth rates (all |R| > 0.78, P < .001).
  • Early CL/CC growth was a stronger predictor of late diameter growth (|R| > 0.72) compared to early diameter growth (|R| < 0.61).

Conclusions:

  • Aortic centerline length and curvature growth are inversely related to aortic diameter growth in chronic TBAD.
  • CL and CC changes may serve as valuable predictive markers for aortic diameter growth in chronic TBAD, potentially improving surgical intervention timing.
Abstract

Keywords:
aortic centerlinecurvaturediametergrowth ratetype B aortic dissection

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