Risk Factors for Anti-Glaucoma Surgery in Posner-Schlossman Syndrome Patients: an 8-Year Retrospective Study

This study identifies older age, higher attack frequency and RNFL defect as risks for anti-glaucoma surgery in 106 Chinese Posner-Schlossman Syndrome (PSS) patients via an 8-year retrospective study.

To investigate the risk factors for anti-glaucoma surgery in Chinese patients with PSS.

Retrospective study. All PSS patients visiting Peking University Third Hospital Department of Ophthalmology between June 2016 and May 2023 with a minimum follow-up of 12 months were enrolled. Patients were divided into low-frequency group and high-frequency group (whether average attacks were less than 2 times/year or not). General information, ocular manifestation and medical treatment were compared between the two groups. Risk factors for anti-glaucoma surgery were analyzed.

Among 106 patients, 62 cases were in the low-frequency group and 44 were in the high-frequency group. Patients in high-frequency group had a longer duration of attacks, more iris atrophy, and systemic administration of ganciclovir (p = 0.044, 0.044, 0.012, respectively). They also had a higher tendency to develop secondary glaucoma and more probability of undergoing anti-glaucoma surgery (p = 0.014, 0.017 respectively). 18 cases (17%) received anti-glaucoma surgery while binary logistic regression showed that the risk factors for receiving anti-glaucoma surgery were elder age of onset (odds ratio (OR) = 1.080; 95% confidence interval (CI): 1.012-1.153; p = 0.021), higher frequency of attacks (OR = 6.186; 95% CI: 1.276, 29.976; p = 0.024), and RNFL defect (OR = 4.804; 95% CI: 1.040, 22.184; p = 0.044).

Risk factors for anti-glaucoma surgery in patients with PSS were elder age of onset, higher frequency of attacks and RNFL defect.