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Updated: May 5, 2026

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Milk Fat Globule-EGF Factor 8 (MFG-E8): A Prominent Modulator of Tissue Repair

Weijian Zhang1,2,3, Yizhe Zhang1,3, Haoliang Wang1,2,3

  • 1The Center of Joint and Sports Medicine, Orthopedics Department, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|May 4, 2026
PubMed

Insights

Milk fat globule-epidermal growth factor 8 (MFG-E8) influences tissue repair through efferocytosis and macrophage polarization. Understanding MFG-E8

Area of Science:

  • Biochemistry
  • Cell Biology
  • Immunology

Background:

  • Milk fat globule-epidermal growth factor 8 (MFG-E8) is a secreted glycoprotein produced by phagocytes.
  • MFG-E8 is found in various mammalian tissues and influences key repair processes.

Purpose of the Study:

  • To review the diverse biological effects of MFG-E8 in tissue repair.
  • To explore the molecular mechanisms underlying MFG-E8's roles in nervous, musculoskeletal, cardiovascular, and digestive systems.
  • To investigate MFG-E8's therapeutic potential and clinical applications.

Main Methods:

  • Literature review of studies on MFG-E8 and tissue repair.
  • Analysis of molecular mechanisms involved in MFG-E8-mediated processes.
  • Evaluation of MFG-E8's dual roles in beneficial and detrimental contexts.

Main Results:

  • MFG-E8 modulates efferocytosis, macrophage polarization, angiogenesis, and oxidative stress.
  • MFG-E8 has beneficial roles in tissue repair but also detrimental effects in pathologies like tumor progression.
  • Specific roles and mechanisms of MFG-E8 vary across different organ systems.

Conclusions:

  • MFG-E8 plays a complex role in tissue repair, with both beneficial and detrimental effects.
  • A comprehensive understanding of MFG-E8 is crucial for developing targeted therapeutic strategies.
  • MFG-E8 presents potential as a therapeutic target for various clinical applications.
Keywords:
efferocytosisinflammationmacrophagemilk fat globule‐epidermal growth factor 8tissue repair

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