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Updated: May 5, 2026
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
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DUSP1 deficiency accelerates UVB‑induced HDF cell senescence by regulating ferroptosis
Wenting Chen1,2, Qi Sun1, Shan Zhang1
1Department of Dermatology, Children's Hospital of Soochow University, Suzhou, 215028, China.
Summary
Ferroptosis, a cell death process, contributes to skin aging caused by ultraviolet B (UVB) radiation. Dual-Specificity Phosphatase 1 (DUSP1) plays a protective role against UVB-induced skin aging by regulating ferroptosis.
Area of Science:
- Dermatology
- Cell Biology
- Biochemistry
Background:
- Ultraviolet (UV) radiation, particularly UVB, is a primary driver of skin aging.
- Ferroptosis, a regulated cell death pathway, has a debated role in UVB-induced skin photoaging.
- Dual-Specificity Phosphatase 1 (DUSP1) is potentially linked to both skin aging and ferroptosis.
Purpose of the Study:
- To investigate the role of ferroptosis in UVB-induced stress-induced premature senescence (UVB-SIPS) in human dermal fibroblasts (HDFs).
- To explore the regulatory mechanism of DUSP1 in UVB-induced photoaging.
- To determine if DUSP1 can be a therapeutic target for mitigating skin aging.
Main Methods:
- Establishing a UVB-SIPS model using HDFs.
- Utilizing the ferroptosis inhibitor ferrostatin-1 (Fer-1).
- Performing in vitro DUSP1 knockdown experiments and analyzing collagen production, cell senescence markers, and the SLC7A11/GPX4 axis.
Main Results:
- UVB irradiation induced ferroptosis in HDFs.
- Ferrostatin-1 treatment reduced UVB-induced senescence and reactive oxygen species (ROS) while increasing collagen production.
- DUSP1 expression decreased post-UVB exposure; DUSP1 knockdown aggravated senescence and reduced collagen, potentially via the SLC7A11/GPX4 pathway.
Conclusions:
- Ferroptosis is implicated in UVB-induced skin photoaging.
- DUSP1 acts protectively against UVB-induced skin aging by modulating ferroptosis.
- DUSP1 represents a potential therapeutic target for combating skin photoaging.
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