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Updated: May 5, 2026
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Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
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The aging eye: navigating molecular mechanisms and innovative interventions
Yumeng Lin1, Zhongyu Han2, Yunfeng Zhang1
1Department of Nanjing Tongren Eye Center, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China.
Biogerontology
|May 4, 2026
Summary
Aging eyes face vision loss from diseases like AMD and cataracts. This review explores molecular aging pathways and new treatments like gene editing and AI diagnostics for better eye care.
Area of Science:
- Ophthalmology
- Gerontology
- Molecular Biology
Background:
- Global aging populations increase age-related eye diseases, including age-related macular degeneration (AMD), cataracts, and dry eye.
- These conditions are driven by molecular aging processes within ocular tissues.
Purpose of the Study:
- To review the molecular mechanisms of ocular aging.
- To highlight advancements in therapeutic strategies and diagnostics for age-related eye diseases.
Main Methods:
- Systematic review of molecular pathways (oxidative stress, senescence, autophagy, epigenetics) in ocular aging.
- Evaluation of emerging translational therapies (gene editing, stem cells, senolytics).
- Exploration of AI in diagnostics for early detection and precision medicine.
Main Results:
- Identified key aging mechanisms: ROS accumulation, SASP, autophagic dysfunction, and epigenetic changes.
- Highlighted potential of gene editing, stem cell therapy, and senolytics.
- Emphasized AI's role in retinal imaging and biomarker analysis for early diagnosis.
Conclusions:
- Integrative approaches combining aging biomarkers and targeted therapies are crucial.
- Precision medicine and advanced diagnostics are key for future geriatric ophthalmic care.
- Tissue-specific drug delivery systems are needed for effective ocular treatment.
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