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Temporal Metabolomics Profiling Reveals Liver Metabolic Control in Single and Repeated Exhaustive Exercise in Murine
Jining Yang1, Dawei Wang1, Hui Shen1
1Research Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Health, Institute of Military Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, China.
Summary
Single exhaustive exercise causes temporary liver metabolic changes, while repeated exercise leads to sustained remodeling and potential injury. Understanding these distinct hepatic responses is key for personalized exercise strategies.
Area of Science:
- Metabolomics
- Exercise Physiology
- Hepatology
Background:
- Excessive exercise can cause metabolic disturbances, with the liver playing a key role in systemic adaptations.
- The liver's dynamic metabolic response to exercise is not well understood, hindering early diagnostic and preventive strategies.
- Characterizing hepatic metabolic shifts is crucial for understanding exercise-induced stress.
Purpose of the Study:
- To systematically delineate temporal metabolic alterations in the murine liver following single exhaustive exercise (SEE) and repeated exhaustive exercise (REE).
- To compare the distinct hepatic metabolic responses and injury patterns induced by SEE versus REE.
- To identify key metabolic pathways and biomarkers associated with exercise-induced liver injury.
Main Methods:
- Mice were subjected to SEE or daily REE for 7 days.
- Liver tissues and serum were collected at multiple time points post-exercise (0-48h).
- Analyses included untargeted metabolomics, histopathology, and liver injury biomarker quantification.
Main Results:
- SEE induced transient metabolic perturbations resolving within 24h.
- REE led to progressive metabolic remodeling, particularly in amino acid metabolism.
- Both SEE and REE caused hepatic injury, with elevated biomarkers early but recovery within 24h for SEE. REE showed sustained elevations.
- Steroid hormone biosynthesis and taurine/hypotaurine metabolism correlated with injury severity.
Conclusions:
- Single exhaustive exercise triggers self-limited hepatic metabolic adjustments.
- Repeated exhaustive exercise induces sustained metabolic remodeling and potential delayed recovery.
- Distinct hepatic metabolic patterns highlight the need for personalized exercise regimens and suggest potential therapeutic targets for mitigating exercise-induced liver stress.
