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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Related Experiment Video

Updated: May 5, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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Biodegradable PCL-PLGA Electrospun Nanofibers for Localized Cancer Therapy.

Rahul Tiwari1,2, Pranav1,2, Joel Delossantos1,2

  • 1Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, Texas 78014, USA.

ACS Applied Bio Materials
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

Electrospun nanofibers made from PCL and PLGA offer a promising platform for localized cancer therapy. Architectural modifications enhance drug delivery, improving efficacy and reducing systemic toxicity.

Keywords:
biodegradable polymerscancer treatmentlocalized chemotherapylung infectionnanofibers

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cancer Therapy

Background:

  • Localized chemotherapy improves efficacy and reduces toxicity after tumor resection.
  • Electrospun nanofibers mimic the extracellular matrix for controlled drug release.

Purpose of the Study:

  • To develop and characterize PCL-PLGA electrospun nanofibers for localized cancer therapy.
  • To investigate the impact of nanofiber architecture on drug release and cytotoxic effects.

Main Methods:

  • Fabrication of PCL, PCL-PLGA blended, and PCL-PLGA multilayered nanofibers.
  • Characterization using SEM, FTIR, and thermal analyses.
  • Drug release studies (curcumin), hemocompatibility, cytocompatibility, and cytotoxicity assays (docetaxel).

Main Results:

  • Uniform nanofiber morphology confirmed; polymer blending and drug incorporation verified.
  • PLGA incorporation modulated degradation and wettability, influencing drug release.
  • Multilayered and blended nanofibers showed reduced burst release and prolonged drug delivery.
  • All formulations exhibited good hemocompatibility and cytocompatibility.
  • Nanofiber architecture significantly impacted drug release profiles and demonstrated high cytotoxic responses.

Conclusions:

  • Architectural and compositional engineering of PCL-PLGA nanofibers creates a versatile platform for localized, sustained cancer therapy.
  • This approach holds potential for enhanced cancer treatment with reduced side effects.