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Updated: May 6, 2026

Determination of the Photoisomerization Quantum Yield of a Hydrazone Photoswitch
Published on: February 7, 2022
Photovermellogens: Minimalistic Pyridinium-Based Acylhydrazones with Photoswitchable Basicity for Operation in
Alejandro Vila1, Francisco G Blandón-Cumbreras2, Mike Pauls3
1CICA - Centro Interdisciplinar de Química e Bioloxía and Departamento de Química, Facultade de Ciencias, Universidade da Coruña, A Coruña 15071, Spain.
Abstract:
Examples of a new class of synthetically straightforward and hydrolytically inert photoswitchable acylhydrazones, named photovermellogens, have been successfully developed and comprehensively studied using state-of-the-art spectroscopic and computational techniques. These compounds present photoswitchable basicity, with irradiation promoting E→Z photoisomerizations, which result in the generation of a less acidic species. The observed ΔpKa values > 1.5 within the biologically relevant window underscore the potential of photovermellogens as versatile platforms for light-triggered pH control.
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