Related Experiment Video
Updated: May 6, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
mTM-align2: A Server for Real-time Protein Structure Database Search and Alignment
Qiuyi Lyu1, Hong Wei2, Shuaishuai Chen3
1MOE Frontiers Science Center for Nonlinear Expectations, State Key Laboratory of Cryptography and Digital Economy Security, Research Center for Mathematics and Interdisciplinary Sciences, Shandong University, Qingdao 266237, China.
None:
Identifying structurally similar proteins from large-scale databases is a fundamental challenge in structural bioinformatics. The recent release of millions of predicted structures by AlphaFold2 presents unprecedented scale and efficiency challenges for existing tools. To address this, we introduce the mTM-align2 server, a significantly upgraded version of mTM-align. This new platform is capable of searching both monomeric and multimeric structures against a comprehensive database of approximately 3 million entries in seconds. mTM-align2 achieves a two- to three-fold increase in search speed while maintaining accuracy comparable to that of other state-of-the-art methods. The server is available at https://yanglab.qd.sdu.edu.cn/mTM-align/.
Related Concept Videos
Protein Organization
The primary structure of a protein is its amino acid sequence....
Peptide Identification Using Tandem Mass Spectrometry
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
Proteomics
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

