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Agreements between 24-2 and 24-2 C test grids for chloroquine/hydroxychloroquine retinopathy patients and high-risk
Chananchida Wongwachira1,2, Disorn Suwajanakorn1,3, Wijak Kongwattananon1,3
1Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Purpose:
To compare the SITA Standard 24-2 and SITA Faster 24-2 C tests in patients with chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy and those at high risk.
Methods:
A prospective, cross-sectional study of 75 participants who underwent CQ/HCQ retinopathy screening using the SITA Standard 24-2, SITA Faster 24-2 C, optical coherence tomography, fundus autofluorescence, and a dilated eye examination on the same day. Participants were categorized into retinopathy and non-retinopathy groups by graders. The agreement between the two visual field (VF) tests was assessed using Bland-Altman plots.
Results:
Among the 75 participants, 10 (13.3%) were diagnosed with CQ/HCQ retinopathy. Bland-Altman plots show good agreement in median deviation (MD), pattern standard deviation (PSD), and central mean sensitivity (CMS) between tests. The concordance coefficient was 0.89-0.93. Significant differences in MD, PSD, and CMS were observed between the retinopathy and non-retinopathy groups for both VF tests (P ≤ 0.02). However, within each group, the results of both VF tests were comparable across all parameters (P = 0.12-0.79), except for PSD in the non-retinopathy group. The SITA Faster 24-2 C test had a significantly shorter testing duration.
Conclusions:
The SITA Standard 24-2 and SITA Faster 24-2 C tests showed similar efficacy and strongly positive agreement in screening for CQ/HCQ retinopathy. However, the SITA Faster 24-2 C minimized the testing time. The addition of testing points within the central 10-degree field did not enhance the detection of CQ/HCQ retinopathy in the Thai population.
