Plant-derived Secondary Metabolites that Delay Dermal Aging in Humans Through Longevity Pathways
Nipuni Dilanka Hennadige1, Thisanja Cooray1, Shalini Wijerathne1
1Institute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka.
Current Aging Science
|May 5, 2026
Summary
Plant compounds show promise for anti-aging benefits by modulating key molecular pathways involved in skin aging. These natural compounds may help delay dermal aging and promote longevity.
Area of Science:
- Dermatology
- Pharmacology
- Biogerontology
Background:
- Skin aging, or dermal aging, is a complex process influenced by genetics and environment.
- It significantly impacts appearance and is linked to overall longevity.
- Plant-derived compounds offer potential therapeutic benefits for aging skin.
Purpose of the Study:
- To review the cellular mechanisms of dermal aging.
- To explore the role of plant secondary metabolites in mitigating skin aging.
- To highlight how these compounds modulate key aging-related molecular players.
Main Methods:
- This narrative review synthesizes existing research on dermal aging and plant-derived compounds.
- It examines the hallmarks of aging at a cellular level.
- It discusses various plant secondary metabolites and their proposed anti-aging mechanisms.
Main Results:
- Plant secondary metabolites possess diverse biological activities with anti-aging potential.
- These compounds can modulate critical molecular targets like MMP, p53, p21, mTOR, and TGF-β.
- Modulation of these targets can influence the rate of dermal aging and potentially longevity.
Conclusions:
- Plant-derived secondary metabolites represent a promising natural resource for anti-aging interventions.
- Targeting specific molecular pathways involved in aging offers a strategy to delay dermal aging.
- Further research into these compounds could lead to novel anti-aging therapies.
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