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Revolutionizing Psoriasis Therapy: Cutting-Edge Nanocarrier Systems, Formulation Strategies, and Future Horizons
Satyam Khare1,2, Akash Vikal1, Rashmi Maurya1
1Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga, 142001, Punjab, India.
Current Pharmaceutical Design
|May 5, 2026
Summary
Nanocarriers like liposomes and nanoparticles offer improved psoriasis treatment by enhancing drug delivery and reducing side effects. Future innovations aim for advanced, personalized nanomedicine for better skin disease management.
Area of Science:
- Dermatology and Nanotechnology
- Drug Delivery Systems
Background:
- Psoriasis involves skin inflammation and cell overgrowth, often poorly treated by traditional therapies due to limited drug penetration and bioavailability.
- Existing treatments face challenges like inadequate skin penetration, systemic toxicity, and poor drug bioavailability.
Purpose of the Study:
- To review recent advancements in nanocarrier-based drug delivery systems for psoriasis treatment.
- To highlight the advantages, formulation strategies, and outcomes of using nanocarriers for psoriasis.
Main Methods:
- Review of recent literature on nanocarrier formulations for psoriasis.
- Analysis of different nanocarrier types (liposomes, SLNs, PNPs, ethosomes) and their mechanisms.
- Evaluation of encapsulated drugs (corticosteroids, immunomodulators, anti-inflammatories).
Main Results:
- Nanocarriers enhance drug stability, prolong release, and enable targeted delivery to psoriatic lesions.
- Liposomes and ethosomes improve skin permeation; SLNs and PNPs provide controlled release and retention.
- Nanocarriers effectively encapsulate various therapeutic agents, leading to improved clinical outcomes.
Conclusions:
- Nanocarrier systems show significant promise for overcoming limitations of traditional psoriasis therapies.
- Challenges include drug-loading, stability, and scalability, requiring further research.
- Future directions involve stimulus-responsive systems, surface functionalization, and AI for precision medicine in psoriasis management.
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