Lansoprazole/β-Cyclodextrin-Based Metal-Organic Frameworks: Development, Characterization, and Anti-Ulcer Activity...

Area of Science:

• Materials Science
• Nanotechnology
• Pharmaceutical Sciences

Background:

• Gastric ulcers are a prevalent global health issue.
• Lansoprazole (LNS) is a primary treatment for gastric ulcers.
• Beta-cyclodextrin-based metal-organic frameworks (β-CD-MOFs) offer potential for enhanced drug delivery.

Purpose of the Study:

• To utilize β-CD-MOFs as carriers for lansoprazole (LNS).
• To enhance the physicochemical properties, release profile, and photostability of LNS.
• To evaluate the anti-ulcerogenic efficacy of the LNS-loaded β-CD-MOF formulation.

Main Methods:

• Preparation and characterization of β-CD-MOF crystals loaded with LNS.
• Physicochemical characterization using DSC, PXRD, FTIR, and SEM.
• In vitro dissolution studies and in vivo anti-ulcer activity evaluation in Wistar rats.

Main Results:

• Successful loading of LNS into β-CD-MOF crystals.
• Enhanced in vitro release of LNS (approx. 90% in 60 minutes) and improved photostability.
• Significant reduction in gastric mucosal lesions and high ulcer index inhibition in vivo.

Conclusions:

• LNS loading into β-CD-MOF improves its release kinetics and photostability.
• The β-CD-MOF formulation exhibits potent anti-ulcerogenic capabilities.
• β-CD-MOFs are promising carriers for improving lansoprazole's therapeutic properties.