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Related Experiment Video

Updated: May 6, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

Anti-D administration after childbirth for preventing Rhesus alloimmunisation for subsequent pregnancies.

Nimisha Kumar¹, Morteza A Khafaie², Shayesteh Jahanfar³

¹Department of Obstetrics and Gynecology, Adovcate Aurora Health, Milwaukee, Wisconsin, USA.

The Cochrane Database of Systematic Reviews

|May 5, 2026

Summary

This review evaluates anti-D immunoglobulin (anti-D) doses and timings to prevent Rhesus (Rh) alloimmunisation in Rh-negative mothers after delivery. It aims to determine the optimal strategy for preventing Rh disease in newborns.

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Area of Science:

Immunology
Obstetrics
Pharmacology

Background:

Rhesus (Rh) alloimmunisation can cause hemolytic disease in newborns.
Prevention strategies are crucial for Rh-negative women carrying Rh-positive infants.

Purpose of the Study:

To assess the efficacy and safety of different anti-D administration protocols.
To identify optimal dosing and timing for preventing Rh alloimmunisation post-childbirth.

Main Methods:

Cochrane Review methodology.
Systematic evaluation of anti-D interventions.
Analysis of benefits and harms.

Main Results:

Data on various anti-D doses and timings are being synthesized.
Evidence regarding the effectiveness of different protocols is under examination.
Safety profiles of anti-D administration are being assessed.

Conclusions:

Findings will inform clinical guidelines for anti-D use.
Optimal anti-D strategies aim to improve neonatal outcomes.
This review will clarify best practices in Rh alloimmunisation prevention.